PT2977 (MK-6482)
3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile
CAS: 1672668-24-4
Molecular Formula: C17H12F3NO4S
PT2977 (MK-6482) - Names and Identifiers
PT2977 (MK-6482) - Physico-chemical Properties
| Molecular Formula | C17H12F3NO4S |
| Molar Mass | 383.34 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Boling Point | 505.8±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 11.66±0.60(Predicted) |
| Storage Condition | -20℃ |
| Use | Belzutifan, also known as PT2977 and MK-6482, is HIF-2alpha inhibitor. PT2977 binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis. Belzutifan was approved in 2021 for treatment of von Hippel-Lindau disease under certain conditions。 |
PT2977 (MK-6482) - Reference
| Reference Show more | 1: Garje R, An JJ, Sanchez K, Greco A, Stolwijk J, Devor E, Rustum Y, Zakharia Y.Current Landscape and the Potential Role of Hypoxia-Inducible Factors andSelenium in Clear Cell Renal Cell Carcinoma Treatment. Int J Mol Sci. 2018 Dec1;19(12). pii: E3834. doi: 10.3390/ijms19123834. Review. PubMed PMID: 30513765. |
PT2977 (MK-6482) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.609 ml | 13.043 ml | 26.086 ml |
| 5 mM | 0.522 ml | 2.609 ml | 5.217 ml |
| 10 mM | 0.261 ml | 1.304 ml | 2.609 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
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Multiple SpecificationsSpot supply
Product Name: PT2977 Visit Supplier Webpage Request for quotationCAS: 1672668-24-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile Visit Supplier Webpage Request for quotation
CAS: 1672668-24-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1672668-24-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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